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Mouse study finds BPA exposure has transgenerational effects on gene linked to autism

Transgenerational bisphenol A (BPA) exposure may contribute to autism, according to a mouse study published in the Endocrine Society's journal Endocrinology.

針對老鼠的研究發現，雙酚A會對自閉癥相關基因產生隔代影響

上海譯銳翻譯   2019-6-24      17:00 p.m.

? Zerbor / Adobe Stock

據在美國內分泌學會期刊《內分泌學》上發表的一篇老鼠研究介紹，隔代接觸雙酚A可能會導致自閉癥。

Endocrine disrupting chemicals (EDCs) are chemicals or mixtures of chemicals that interfere with the way the body's hormones work. BPA is a common EDC used in plastics and food storage material, and it is already present in most humans' urine or blood. Animal studies have linked BPA to anxiety, aggression, and poor learning and social interactions. Studies of human populations report associations between BPA and neurobehavioral issues like attention deficit hyperactivity disorder and autism.

內分泌干擾物是一種會干擾人體荷爾蒙工作方式的化學物質或化學物質混合物。雙酚A是一種常見的、用于塑料和食品存儲材料中的內分泌干擾物。絕大多數人的尿液或血液中都存在雙酚A。動物研究發現雙酚A與憂慮、攻擊以及學習和社交能力不足有關。有關人類種群的研究發現雙酚A和神經行為問題，如注意力缺陷多動癥和自閉癥有關聯。

"Exposure of mouse fetuses to BPA disrupts formation of nerve cell connections in the brain, and this is a transgenerational effect," said the study's senior author, Emilie F. Rissman, Ph.D., of University of Virginia School of Medicine in Charlottesville, Va. and North Carolina State University in Raleigh, N.C. "To put this in human terms, if your great grandmother was exposed to BPA during her pregnancy and none of your other relatives ever came into contact with BPA, your brain would still show these effects."

Emilie F. Rissman，本研究資深作者、弗吉尼亞州夏洛特維爾弗吉尼亞大學藥學院以及北卡羅萊納羅利市北卡羅來納州立大學的博士，表示：“老鼠胎兒在接觸到雙酚A后，雙酚A會擾亂大腦中神經細胞的連接并且會產生隔代影響。拿人類來說，如果你的曾祖母在懷孕時曾接觸過雙酚A并且你的其他任何親戚都沒有接觸過雙酚A，你的大腦仍會受此影響。”

In this mouse study, researchers tested mice descended from those exposed to BPA for social recognition and found that they showed a social behavioral deficient like autistic behavior. Mice whose great grandmothers were exposed to BPA during pregnancy were more active and took longer to habituate to strangers than other mice. More strikingly, they didn't explore the new mice that were introduced to the group. Mice are very social and curious, so this is an exciting finding.

在本次的老鼠研究中，研究人員測試了接觸過雙酚A的老鼠后代的社會認同能力并發現，這些后代表現出一種類似于自閉行為的社交行為缺乏現象。曾祖母在孕期曾接觸過雙酚A的老鼠更加多動并且需要比其他老鼠花更多時間來適應陌生人。更為明顯的是，這些老鼠不會去探查來到鼠群的新老鼠。老鼠是一種非常具有社交能力和好奇的動物，因此這是一個讓人非常興奮的發現。

"Even if we ban all BPA right now, that will not change these long-term effects on the brain," Rissman said.

Rissman表示：“即使我們立刻禁止所有的雙酚A，都無法改變其對大腦所產生的長期影響。”

 The study received funding support from the National Institutes of Health and the Environmental Protection Agency.

本研究獲得了來自美國國家衛生研究院和美國國家環境保護局的資金支持。

要了解的詞：

transgenerational effect：隔代影響

Autism：自閉癥

Endocrine disrupting chemicals：自閉癥干擾物

BPA：雙酚A

attention deficit hyperactivity disorder:：注意力缺陷多動癥

內容來源：科學時報   編輯：質控部Susan